Carol Duffy
biological sciences
University of Alabama
United States of America
Biography
Ph.D., Microbiology, University of Iowa, 2000 Postdoctoral research: Cornell University
Research Interest
My research interests lie in elucidating the mechanisms used by herpes simplex virus type 1 (HSV-1) to replicate within its host. The herpesviruses have been co-evolving with their hosts for millions of years, and have consequently developed elaborate mechanisms for replication and evasion of their hosts’ defense systems. HSV-1 is a neurotropic herpesvirus that infects ~80% of young adults worldwide. Infection of its human host is initiated with a lytic infection of the mucosal epithelium and continues through invasion of the peripheral nervous system that usually leads to establishment of a reactivatable latent infection. On occasion, HSV-1 spreads to the central nervous system, causing the most common type of sporadic viral encephalitis seen in western countries. In addition, HSV-1 can infect the corneal epithelium, causing a disease known as herpes simplex keratitis that often results in vision damage.
Publications
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Mbong EF, Woodley L, Frost E, Baines JD, Duffy C. Deletion of UL21 causes a delay in the early stages of the herpes simplex virus 1 replication cycle. J Virol. 2012 Jun;86(12):7003-7.
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Mbong EF, Woodley L, Dunkerley E, Schrimpf JE, Morrison LA, Duffy C. Deletion of the herpes simplex virus 1 UL49 gene results in mRNA and protein translation defects that are complemented by secondary mutations in UL41. J Virol. 2012 Nov;86(22):12351-61.
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Dewberry EJ, Dunkerley E, Duffy C. Purification of full-length VP22 from cells infected with HSV-1: A two-pronged approach for the solubilization and purification of viral proteins for use in biochemical studies. J Virol Methods. 2012 Aug;183(2):180-5.
