Catherine Clarke
Professor
Chemistry and Biochemistry
University of California los Angeles
United States of America
Biography
Professor Clarke has been a faculty member in the Department of Chemistry and Biochemistry since 1993. Dr. Clarke completed her undergraduate and graduate studies at UCLA. Her Ph.D. studies focused on the regulation of cholesterol metabolism. She was a post-doctoral fellow at Princeton University. She returned to UCLA in the Department of Medicine and studied polyisoprene and non-sterol metabolism, and then initiated studies on coenzyme Q biosynthesis using the yeast model. In 1993 she joined the Department of Chemistry and Biochemistry and the Molecular Biology Institute. She was promoted to full professor in 2002, and has served as General Chemistry Advisor and Biochemistry Graduate Student Advisor.
Research Interest
The focus of her current research is determining how cells synthesize coenzyme Q, and utilizing yeast and nematode models to understand mechanisms of its inter- and intra-cellular transport, and elucidating functional roles.
Publications
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Hill Shauna, Lamberson Connor R, Xu Libin, To Randy, Tsui Hui S, Shmanai Vadim V, Bekish Andrei V, Awad Agape M, Marbois Beth N, Cantor Charles R, Porter Ned A, Clarke Catherine F, Shchepinov Mikhail S Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation Free Radical Biology & Medicine, 2012; 53(4): 893-906.
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Nguyen Theresa P T, Clarke Catherine F Folate status of gut microbiome affects Caenorhabditis elegans lifespan BMC Biology, 2012; 10(4): 66.
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Gomez Fernando, Saiki Ryoichi, Chin Randall, Srinivasan Chandra, Clarke Catherine F Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation Gene, 2012; 506(1): 106-16.
