James Wohlschlegel
Assistant Professor
Biological Chemistry
University of California los Angeles
United States of America
Biography
James Wohlschlegel received his B.S. in Biochemistry from Texas A&M University (College Station, TX) in 1997. He then went to graduate school at Harvard Medical School (Boston, MA) where he studied protein complexes regulating the initiation of DNA replication in the laboratory of Anindya Dutta. After completing his Ph.D. in 2002, James went to the Scripps Research Institute (La Jolla, CA) for postdoctoral training under the co-mentorship of John Yates (proteomic mass spectrometry) and Steven Reed (cell cycle regulation). James joined the Department of Biological Chemistry as an assistant professor in 2006.
Research Interest
Signaling networks have emerged as the underlying regulatory system by which the many biological pathways required for sustaining life are coordinated. The Wohlschlegel laboratory uses a combination of biochemistry and proteomic mass spectrometry to understand the signaling networks mediated by the ubiquitin family of small protein modifications. Specifically, they are examining the role of two members of this family, ubiquitin and SUMO, in regulating key nuclear processes. Importantly, the deregulation of these two modification systems has been linked to the pathogenesis of many diseases including cancer, neurodegenerative diseases, and immune system disorders.
Publications
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Thivierge Caroline, Makil Neetha, Flamand Mathieu, Vasale Jessica J, Mello Craig C, Wohlschlegel James, Conte Darryl, Duchaine Thomas F Tudor domain ERI-5 tethers an RNA-dependent RNA polymerase to DCR-1 to potentiate endo-RNAi Nature structural & molecular biology, 2013; 20(2): 244.
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Kim Myoung Shin, Machida Yuka, Vashisht Ajay A, Wohlschlegel James A, Pang Yuan-Ping, Machida Yuichi J Regulation of error-prone translesion synthesis by Spartan/C1orf124 Nucleic acids research, 2013; 41(3): 1661-8.
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Beck Josh R, Fung Connie, Straub Kurtis W, Coppens Isabelle, Vashisht Ajay A, Wohlschlegel James A, Bradley Peter J A Toxoplasma Palmitoyl Acyl Transferase and the Palmitoylated Armadillo Repeat Protein TgARO Govern Apical Rhoptry Tethering and Reveal a Critical Role for the Rhoptries in Host Cell Invasion but Not Egress PLoS pathogens, 2013; 9(2): e1003162.
