Steve Cole
Professor of Medicine
Hematology-Oncology
University of California los Angeles
United States of America
Biography
Steve Cole is a Professor of Medicine and Psychiatry and Biobehavioral Sciences in the UCLA School of Medicine. His research studies the molecular pathways by which social environments influence gene expression by viral, cancer, and immune cell genomes. Cole's research has mapped the pathways by which social factors enhance replication of viruses (e.g., HIV-1 and HHV-8), alter expression of key immune response genes (e.g., IL6 and IFNB), and up-regulate cancer progression and metastasis (e.g., in breast and ovarian cancers). He has developed an array of bioinformatics tools to facilitate these analyses, including Transcript Origin Analysis (to identify the cellular sources of differentially expressed genes), the Transcription Element Listening System (TELiS; to identify transcription factors mediating differential gene expression), and the GEscan algorithm (to identify genetic polymorphisms that affect transcriptional responses to environmental stimuli). Dr. Cole received his Ph.D. in Psychology from Stanford University in 1993 and subsequently completed 5 years of Post-Doctoral Fellowship research in psycho-neuro-immunology at UCLA. He served as an Assistant Research Biologist (1998), Assistant Professor (2001), Associate Professor (2006), and Professor of Medicine (2011) at UCLA. In addition to his appointments in the Division of Hematology-Oncology in the UCLA Department of Medicine and the Department of Psychiatry and Biobehavioral Sciences, Dr. Cole is also a member of the Jonsson Comprehensive Cancer Center, the Norman Cousins Center, the UCLA AIDS Institute, and the UCLA Molecular Biology Institute.
Research Interest
He is a Fellow of the American Association for the Advancement of Science and the Academy of Behavioral Medicine Research. Dr. Cole also serves as Director of the UCLA Social Genomics Core Laboratory, and provides consulting support on social regulation of gene expression to the Institute of Medicine, the National Cancer Institute, the National Institute on Aging, the Santa Fe Institute for Complex Systems, and the MacArthur Foundation, among others.
Publications
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Armaiz-Pena Guillermo N, Gonzalez-Villasana Vianey, Nagaraja Archana S, Rodriguez-Aguayo Cristian, Sadaoui Nouara C, Stone Rebecca L, Matsuo Koji, Dalton Heather J, Previs Rebecca A, Jennings Nicholas B, Dorniak Piotr, Hansen Jean M, Arevalo Jesusa M G, Cole Steve W, Lutgendorf Susan K, Sood Anil K, Lopez-Berestein Gabriel Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth Oncotarget, 2015; 6(6): 4266-73.
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Knight Jennifer M, Rizzo J Douglas, Logan Brent R, Wang Tao, Arevalo Jesusa M G, Ma Jeffrey, Cole Steve W Low Socioeconomic Status, Adverse Gene Expression Profiles, and Clinical Outcomes in Hematopoietic Stem Cell Transplant Recipients Clinical cancer research : an official journal of the American Association for Cancer Research, 2016; 22(1): 69-78.
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Laudenslager Mark L, Simoneau Teresa L, Philips Sam, Benitez Patrick, Natvig Crystal, Cole Steve A randomized controlled pilot study of inflammatory gene expression in response to a stress management intervention for stem cell transplant caregivers Journal of behavioral medicine, 2016; .
