Willy Hugo
Professor
Dermatology
University of California los Angeles
United States of America
Biography
Dr. Hugo's PhD and postdoctoral work on computational biology and large “omic” cancer data sets have prepared him particularly well for a scientific career that capitalizes on the burgeoning informatics revolution in cancer research. His PhD work focused on protein interaction patterns based on protein domains and protein short linear motifs (SLiMs). After his PhD, he started to shift his research focus to cancer informatics with strong emphasis on metastatic melanoma; the “poster child” of a difficult-to-treat human malignancy.
Research Interest
His current work focuses on analyzing the genome, transcriptome, methylome, regulome and proteome of patient and melanoma models (murine, patient-derived xenografts, cell lines) to nominate and validate genes and pathways which affect melanoma's sensitivity/resistance toward targeted-, epigenetic- and immunotherapies. His work ultimately aims towards translation of such knowledge to improve patient treatment outcome.
Publications
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Shi Hubing, Hugo Willy, Kong Xiangju, Hong Aayoung, Koya Richard C, Moriceau Gatien, Chodon Thinle, Guo Rongqing, Johnson Douglas B, Dahlman Kimberly B, Kelley Mark C, Kefford Richard F, Chmielowski Bartosz, Glaspy John A, Sosman Jeffrey A, van Baren Nicolas, Long Georgina V, Ribas Antoni, Lo Roger S Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy Cancer discovery, 2014; 4(1): 80-93.
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Moriceau Gatien, Hugo Willy, Hong Aayoung, Shi Hubing, Kong Xiangju, Yu Clarissa C, Koya Richard C, Samatar Ahmed A, Khanlou Negar, Braun Jonathan, Ruchalski Kathleen, Seifert Heike, Larkin James, Dahlman Kimberly B, Johnson Douglas B, Algazi Alain, Sosman Jeffrey A, Ribas Antoni, Lo Roger S Tunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction Cancer cell, 2015; 27(2): 240-56.
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Hugo Willy, Zaretsky Jesse M, Sun Lu, Song Chunying, Moreno Blanca Homet, Hu-Lieskovan Siwen, Berent-Maoz Beata, Pang Jia, Chmielowski Bartosz, Cherry Grace, Seja Elizabeth, Lomeli Shirley, Kong Xiangju, Kelley Mark C, Sosman Jeffrey A, Johnson Douglas B, Ribas Antoni, Lo Roger S Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma Cell, 2016; 165(1): 35-44.
