William Debello
Professor
Center for Neuroscience Neurobiology, Physiology and Behavio
University of California
United States of America
Biography
Plasticity and learning, auditory system, human physiology, seminar speaking.
Research Interest
Our current goal is to reconstruct the complete wiring diagram of local circuits in the barn owl auditory localization pathway. This is a classic model system for studying the neural bases of information processing, plasticity and learning. Our integrative approach combines in vivo electrophysiology, auditory and visual receptive field mapping, tracer injection, immmunohistochemistry, confocal microscopy, automated transmission electron microscopy, 3D visualization, computer simulation and bootstrap analysis. We hope to better understand how individual life experience is encoded by changes in wiring patterns, and by extension, to shed light on principles of neural processing that are employed across brain regions and across species.
Publications
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Swofford JA and DeBello WM. (2007) Transcriptome changes associated with instructed learning in the barn owl auditory localization pathway. Developmental Neurobiology 67(11):1457-77.
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McBride TJ, Rodriguez-Contreras A, Trinh A, Bailey R and DeBello WM (2008) Learning drives differential clustering of axodendritic contacts in the barn owl auditory system. Journal of Neuroscience 28(27):6960-73.
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Nichols GS and DeBello WM (2008) Bidirectional regulation of the cyclic-AMP response element binding protein encodes spatial map alignment in prism-adapting barn owls. Journal of Neuroscience 28(40):9898-9909.
