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Walid Khaled

Doctor
Pharmacology
University of Cambridge
United States of America

Biography

I read for my undergraduate degree at the University of Edinburgh followed by a Masters degree at Imperial College, London working with Prof. Eric Lam on the PI3K pathway and cell cycle regulation (2001-2002). I did my PhD training with Prof. Christine Watson, Department of Pathology, University of Cambridge where I focused on the role of Stat6 in mammary gland development (2002-2007). After my PhD, I was awarded a junior research fellowship at King's College, Cambridge (2008-2012). The fellowship allowed me to stay for a short post-doc with Prof. Watson during which I identified a novel cell fate regulator Zfp157 (2007-2009). In 2009 I joined the Sanger Institute to work with Dr. Pentao Liu. During my time at Sanger I worked on the connection between cell fate regulation and breast cancer development particularly focusing on the transcription regulator BCL11A. In October 2013, I was appointed as a University Lecturer and group leader at the Department of Pharmacology, University of Cambridge. In May 2014 I was awarded a CRUK Career Establishment Award to investigate the cellular and molecular drivers of breast cancer heterogeneity with a particular focus on the development of novel therapies for triple negative breast cancer (TNBC). I also have a collaboration with Dr. Ewan St John Smith (Department of Pharmacology) and Dr. Kosuke Yusa (Sanger Institute) to identify tumour suppressor genes in the naked mole-rat.

Research Interest

TNBC, Cancer biology, Cancer therapeutics, Proteomics, Genetic screens.

Publications

  • Yong Yu*, Juexuan Wang*, Walid T. Khaled*,Shannon Burke, Peng Li, Xiongfeng Chen, Wei Yang, Nancy Jenkins, Neal Copeland, Shujun Zhang and Pentao Liu. Bcl11a is essential for lymphoid development and negatively regulates p53. 2012 Journal of Experimental Medicine

  • Khaled WT# and Pentao Liu. Cancer Mouse Models: Past, Present and Future. Seminars in Cell and Developmental Biology. 2014

  • Khaled, WT#, Lee SC et al. (2015) BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells. Nature Communications doi: 10.1038/ncomms6987

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