Aditi Das
Assistant Professor
Division of Nutritional Sciences
University of Illinois at urbana champaign
United States of America
Biography
Aditi received her Ph.D in Chemistry at Princeton University. She pursued her postdoctoral research with Dr. Stephen Sligar at University of Illinois Urbana Champaign (UIUC). In 2012, Aditi started her own independent research group in the Department of Comparative Biosciences at UIUC. She is an affiliate faculty in the Department of Biochemistry, Department of Bioengineering, Center for Biophysics and Quantitative Biology, Neuroscience Program, Division of Nutritional Sciences and Beckman Institute.
Research Interest
Dietary consumption of ω-3 and ω-6 fatty acids changes the overall physiology in animals and humans. One of the pathways to change the overall physiology is the conversion of ω-3 and ω-6 fatty acids into epoxide derivatives via the enzymes in the epoxygenase (EPOX) pathway. Most of these epoxides are anti-inflammatory in nature. The prime research direction in our laboratory is to elucidate the biochemical mechanism of the enzymes in the EPOX pathway and to study the biological role of the novel anti-inflammatory ω-3 and ω-6 fatty acid epoxides. Another important research direction in the laboratory is the study of endocannabinoid metabolism by cytochrome P450 leading to the discovery of novel endocannabinoid epoxides that are anti-inflammatory and vasodilatory.
Publications
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McDougle, D., Kambalayal, A., Meling, D. and Das, A*. "Endocannabinoids - Anandamide and 2- Arachidonoylglycerol are Substrates for Human CYP2J2 Epoxygenase" Journal of Pharmacology and Experimental Therapeutics, 2014, 616-27.
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Lim, SJ, McDougle, D., Das, A* and Smith, A.*, "Lipoprotein Nanoplatelets: Fluorescent, Zwitterionic Probes for Molecular and Cellular Imaging." J. Am. Chem. Soc., 2016, 138 (1), pp 64–67.
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Arnold, W., Baylon, J, Tajkorshid, E.* and Das, A.*,"Docosahexaenoic acid (DHA) preferentially binds to cardiovascular CYP2J2 and inhibits arachidonic acid (AA) metabolism" Biochemistry. 2016, 55(50):6969-6980.
