Douglas Darling
Professor
Oral Immunology & Infectious Diseases
University of Louisville
United States of America
Biography
Dr. Douglas S. Darling received his PhD from the University of Washington, Seattle, WA, in 1983. This was followed by postdoctoral work at the University of Chicago Pritzker School of Medicine (to 1987) and in the Howard Hughes Medical Institute at Harvard School of Medicine (to 1992). Dr. Darling is currently a Professor at the University of Louisville School of Dentistry where he directs the ULSD Oral Biology Graduate Program. He is a member of the ULSD Center for Oral Health and Systemic Disease, as well as the Birth Defects Center. He directs a graduate course on experimental design. Dr. Darling is a molecular biologist and has directed research grants investigating molecular mechanisms in salivary gland differentiation, palate morphogenesis, eye development, and gene transcription. He has over 70 publications
Research Interest
differentiation of salivary cells induced tumourigenesis
Publications
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Sztukowska MN, Ojo A, Ahmed S, Carenbauer AL, Wang Q, Shumway B, Jenkinson HF, Wang H, Darling DS, Lamont RJ. Porphyromonas gingivalis initiates a mesenchymalâ€like transition through ZEB1 in gingival epithelial cells. Cellular microbiology. 2016 Jun 1;18(6):844-58.
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Chen Y, Lu X, Montoya-Durango DE, Liu YH, Dean KC, Darling DS, Kaplan HJ, Dean DC, Gao L, Liu Y. ZEB1 Regulates Multiple Oncogenic Components Involved in Uveal Melanoma Progression. Scientific Reports. 2017 Mar 3;7(1):45.
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de Barrios O, Győrffy B, Fernández-Aceñero MJ, Sánchez-Tilló E, Sánchez-Moral L, Siles L, Esteve-Arenys A, Roué G, Casal JI, Darling DS, Castells A. ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1. Gut. 2016 Dec 13:gutjnl-2015.
