Jeffrey D. Hasday, Md
Professor
Medicine
University of Maryland Medical Center
United States of America
Biography
Dr. Hasday is Board-certified in Internal Medicine, Pulmonary Medicine and Critical Care Medicine and is Head of the Pulmonary and Critical Care Medicine Division. He over 30 years experience as a pulmonary and critical care physician with clinical expertise in with acute lung injury/ARDS, sepsis/septic shock, interstitial lung disease, and asthma. His basic and translational research focuses on thermobiology, the effects of clinically relevant hypothermia and hyperthermia (including fever) on biological processes that contribute to homeostasis and disease pathogenesis. Specific research interests include p38 MAP kinase signaling and development of substrate-selective p38 inhibitors, TRPV4, endothelial barrier function, regulation of cytokine expression, acute lung injury, regulation of heat shock protein gene expression, therapeutic hypothermia in ARDS, and thermoregulation. Dr. Hasday also directs the University of Maryland Cytokine Core Laboratory
Research Interest
ARDS, ILD, IPF, interstitial lung disease, asthma, heat shock protein, p38 MAP kinase, endothelial, epithelial, cytokine, thermoregulation
Publications
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Cooper ZA, Ghosh A, Gupta A, Maity T, Benjamin IJ, Vogel SN, Hasday JD, Singh IS. Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-{kappa}B recruitment to cytokine gene promoters. Am J Physiol Cell Physiol. 2010 Jan;298(1):C171-81. PubMed PMID: 19846753; PubMed Central PMCID: PMC2806152.
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Singh IS, He JR, Calderwood S, Hasday JD. A high affinity HSF-1 binding site in the 5'-untranslated region of the murine tumor necrosis factor-alpha gene is a transcriptional repressor. J Biol Chem. 2002 Feb 15;277(7):4981-8. PubMed PMID: 11734555.
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Singh IS, Viscardi RM, Kalvakolanu I, Calderwood S, Hasday JD. Inhibition of tumor necrosis factor-alpha transcription in macrophages exposed to febrile range temperature. A possible role for heat shock factor-1 as a negative transcriptional regulator. J Biol Chem. 2000 Mar 31;275(13):9841-8. PubMed PMID: 10734139.
