Alexandros Poulopoulos

Biography

Our research aims at understanding how neurons form connections in the brain to create circuitry that serves sensation, cognition, and behavior. The phenomena underlying circuit formation straddle multiple levels of magnitude and time, giving rise to "complexes" and "dynamics". These different levels are hierarchically bound together through a series of emergent properties that arise from interacting molecules, subcellular structures, cells, and circuits, to ultimately produce the brain and its functionalities. Our experiments examine how these different levels relate to each other and how they drive the initial formation and life-long modification of brain circuitry.

Research Interest

Neuron cell biology, circuit development, cerebral cortex, growth cone, synaptogenesis, cell adhesion, signal transduction, local translation, CRISPR/Cas9, proteomics, RNAseq, in utero electroporation, live imaging, transplantation, synthetic biology.