Michele Markstein
Assistant Professor
Biology
University of Massachusetts at Amherst
United States of America
Biography
The Markstein lab seeks to understand the stem cell properties of cancer cells with the goal of developing new cancer therapeutics. We focus on cell-cell interactions within the stem cell microenvironment and on the plasticity of stem cell genome architecture. Our approach is in vivo, using the fruit fly Drosophila melanogaster to screen for anti-cancer drugs and drug targets.
Research Interest
Stem Cells and Cancer
Publications
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Markstein, M. 2013. Modeling colorectal cancer as a 3-dimensional disease in a dish: the case for drug screening using organoids, zebrafish, and fruit flies. Drug Development Today: Technologies, e73-81.
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Markstein, M., Dettorre, S., Cho, J., Neumüller, R.A., Craig-Müller, S., Perrimon, N. Systematic screen of chemotherapeutics in Drosophila stem cell tumors. PNAS, 25: 111(12):4530-5.
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Amcheslavsky, A., Nie, Y., Li, Q., He, F., Tsuda, L., Markstein, M., Ip, Y.T. 2014. Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila. Development, 141(13): 2621-32.
