Lamya Karim
Assistant Professor‌
Bioengineering
University of Massachusetts Dartmouth
United States of America
Biography
Ph.D. in Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY B.E. in Biomedical Engineering, Stony Brook University, Stony Brook, NY
Research Interest
Skeletal fragility in patients with type 2 diabetes is a growing public health issue. The prevalence of diabetes is increasing rapidly, and diabetics have three times greater fracture risk compared to non-diabetics. The causes of diabetic skeletal fragility are not well established, which makes it difficult for clinicians to make decisions regarding fracture prevention in this population. Numerous micro-scale changes may contribute to skeletal health issues in these patients. For instance, changes in bone matrix composition due to accumulation of non-enzymatic chemical crosslinks can lead to poor bone quality and in turn deteriorate bone’s mechanical integrity. These crosslinks can also lead to an increase in the formation of micro-scale damage within bone. Further, some patients have altered bone microarchitecture that could contribute to their increased fracture risk, and these microarchitectural changes may result from altered bone cell behavior. Thus, we aim to investigate the biomolecular and cellular mechanisms of skeletal fragility in diabetes and other major clinical conditions. The ultimate goal of our research is to help improve diagnostic methods for facture risk assessment and clinical management of patients at risk for fracture.
Publications
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Heterogeneous glycation of cancellous bone and its association with bone quality and fragility L Karim, D Vashishth - PLoS One, 2012
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Role of trabecular microarchitecture in the formation, accumulation, and morphology of microdamage in human cancellous bone L Karim, D Vashishth - Journal of Orthopaedic Research, 2011
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Role of trabecular microarchitecture in the formation, accumulation, and morphology of microdamage in human cancellous bone L Karim, D Vashishth - Journal of Orthopaedic Research, 2011
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Adolescent girls with anorexia nervosa have impaired cortical and trabecular microarchitecture and lower estimated bone strength at the distal radius AT Faje, L Karim, A Taylor, H Lee, KK Miller, N Mendes… - The Journal of Clinical Endocrinology & Metabolism, 2013
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A review of rodent models of type 2 diabetic skeletal fragility RJ Fajardo, L Karim, VI Calley, ML Bouxsein - Journal of Bone and Mineral Research, 2014
