Maolin Guo
PROFESSOR
Chemistry and Biochemistry
University of Massachusetts Dartmouth
United States of America
Biography
Research in this lab is in the interface between chemistry, biology and medicine. This exciting field is the foundation of modern biomedical sciences which provide molecular basis for various biomedical processes. We are using multi-disciplinary approach including molecular biology, protein chemistry, synthetic and electro-chemistry, spectroscopy (NMR, UV-vis, CD, fluorescent, etc), chromatography and X-ray crystallography to investigate the molecular basis of certain genes, proteins, metal ions and signal transduction pathways related to cancer, aging, infectious, cardiovascular diseases and neurodegenerative disorders. Our research goal is to understand the molecular basis of these biochemical processes and to develop novel strategies for diagnostics and therapeutics.
Research Interest
Biochemistry and Molecular Biology, Protein Engineering, Structural Biology, Bioinorganic Chemistry & Metals in Biology and Medicine
Publications
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ssembly of an Oxo Zirconium(IV) cluster in a protein cleft W. Zhong, D. Alexeev D, I Havey, M. Guo, D. Hunter, H. Zhu, D. Campopiano, P. Sadler, Angew. Chem. Int Ed., 2004, 43, 5914-5918
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Double-strand hydrolysis of DNA by a magnesium (II) complex with diethylenetriamine. P. Yang*, R. Ren, M. Guo*, A. Song, X. Meng, C. Yuan, Q. Zhou, H. Chen, Z. Xiong, X. Gao, J. Biol. Inorg. Chem. 2004, 9, 495-506
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Synergistic anion and metal binding to the ferric-ion binding protein from Neisseria gonorrheae M. Guo, I. Harvey, W. Yang, L. Coghill, D. Campopiano, J. A. Parkinson, R. MacGillivray, W. Harris, P. J. Sadler J. Biol. Chem., 2003, 278, 2490-2502
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Direct assessment of the reduction potential of the [4Fe-4S]1+/0 couple of the Fe protein from Azotobacter vinelandii. M. Guo, F. Sulc, M. Ribbe, P. J. Farmer, B. K. Burgess J. Am. Chem. Soc., 2002, 124, 12100-12101
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The FeMoco-deficient MoFe protein produced by a nifH-deletion strain of Azotobacter vinelandii shows unusual P-cluster features M. Ribbe, Y. Hu, M. Guo, B. Schmid, B. K. Burgess J. Biol. Chem., 2002, 277, 23469-23476
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Ti(IV) targets phosphoesters on nucleotides: implications for the mechanism of action of anticancer drug titanocene dichloride M. Guo, Z. Guo, P. J. Sadler J. Biol. Inorg. Chem., 2001, 6, 698-707
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Understanding the mechanism of action of the anticancer drug titanocene dichloride: TiIVuptake and release by human serum transferrin and Ti2-hTF uptake by cancer cells M. Guo, H. Sun, H. McArdle, L. Gambling, P. J. Sadler Biochemistry, 2000, 33, 10023-10033
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Stereo-selective formation of seven-coordinate titanium(IV) monomer and dimer complexes of ethylenebis(o-hydroxyphenyl)glycine M. Guo, H. Sun, S. Bihari, J. Parkinson, R. Gould, S. Parsons, P. J. Sadler Inorganic Chemistry, 2000, 39, 206-215
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Competitive binding of the anticancer drug titanocene dichloride to N,N´-ethylene-bis- (o-hydroxyphenylglycine) and adenosine triphosphate: a model for TiIV uptake and release by transferrin M. Guo and P. J. Sadler J. Chem. Soc., Dalton Trans., 2000, 7-10
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Interactions of organometallic anticancer agents with nucleotides and DNA P. Yang and M. Guo Coordination Chemistry Reviews, 1999, 186, 189-211
