Shuowei Cai
Associate Professor‌
Bioanalytical chemistry and Biochemistry
University of Massachusetts Dartmouth
United States of America
Biography
Shuowei Cai Ph.D., Biological Chemistry, University of Massachusetts Amherst, Amherst, MA, 2001Dissertation: Molecular Mechanisms of the Activation of Type A Botulinum Neurotoxin Endopeptidase, M.S., Chemistry, University of Massachusetts Dartmouth, Dartmouth, MA, 1998, M.S., Analytical Chemistry, Nankai Univerity, Tianjin, P. R. China, 1993, B.S.,Chemistry, Nankai University, Tianjin, P. R. China, 1990. He is working as an Assistant Professor, Department of Chemistry and Biochemistry, University of Massachusetts Dartmouth.
Research Interest
Bioanalytical and biophysical chemistry, protein chemistry, drug formulation, and pharmaceutical biotechnology, Drug Discovery, Clostridial neurotoxins, Botulinum neurotoxins.
Publications
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Fu, F. N., Lomneth, R. B., Cai, S., Singh, B. R. (1998) Role of zinc in the structure and toxic activity of botulinum neurotoxin., Biochemistry, 37 , 5267-5278
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Cai, S., Sarkar, H. K., Singh, B. R. (1999) Enhancement of the endopeptidase activity of botulinum neurotoxin by its associated proteins and dithiothreitol, Biochemistry, 38 , 6903-6910 .
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Cai, S., Singh, B. R. (1999) Identification of beta-turn and random coil amide III infrared bands for secondary structure estimation of proteins , Biophys. Chem. 80, 7-20.
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Cai, S., Singh, B. R. (2001) A Correlation between Differential Structural Features and the Degree of Endopeptidase Activity of Type A Botulinum Neurotoxin in Aqueous Solution, Biochemistry; 40, 4693-4702..
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Cai, S., Singh, B. R. (2001) Role of the Disulfide Cleavage Induced Molten Globule State of Type A Botulinum Neurotoxin in Its Endopeptidase Activity, Biochemistry, 40, 15327-15333
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Poirier, M. A. , Li, H., Macosko, J., Cai, S., Amzel, M., and Ross, C. A. (2002) Huntingtin Spheroids and Protofibrils as Precursors in Polyglutamine Fibrilization, J. Biol. Chem ., 277 , 41032-41037.
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Cai S., Singh, B. R. (2004) A Distinct Utility of Amide III Infrared Band for Secondary Structure Estimation of Aqueous Protein Solutions Using Partial Least Square Methods, Biochemistry , 43 , 2541-2549
