Kaushik Ragunathan
Assistant Professor
Biological Chemistry
University of Michigan
United States of America
Biography
Postdoctoral fellow, Department of Cell Biology, Harvard Medical School. Ph.D, Biophysics and Computational Biology, University of Illinois, Urbana-Champaign. B.Tech, Biotechnology, PSG College of Technology, India.
Research Interest
My lab is interested in the molecular mechanisms that define how the combinatorial logic of histone modifications and its dynamic interactions with histone binding proteins encodes stable and heritable patterns of gene expression. We take a multidisciplinary perspective that synthesizes genetics, biochemistry and biophysical approaches to capture cellular processes across different spatial and temporal regimes.
Publications
-
Lee, J., S. Lee, K. Ragunathan, C. Joo, T. Ha and S. Hohng, “Single-molecule four-color FRETâ€, Angew. Chem. Int. Ed. 49(51), 9922-9925 (2010)
-
Ragunathan,K., C. Joo and T.Ha, “Real time observation of strand exchange reaction with high spatiotemporal resolutionâ€, Structure 19(8) 1064-73 (2011)
-
S.Kim , K. Ragunathan , J. Park , C. Joo , D. Kim , and T. Ha “Cooperative conformational transitions keep RecA filament active during ATPase cycle†J. Am. Chem. Soc., 136 (42), pp 14796–14800 (2014) H. Kim, S.C. Abeysirigunawarden, K. Chen, M. Mayerle, K. Ragunathan, Z. Luthey-Schulten, T. Ha , S.A. Woodson, “Protein-guided RNA dynamics during early ribosome assemblyâ€, Nature 506, 334–338 (2014) News and Views: Kathleen B. Hall "Molecular biology: Protein binding cannot subdue a lively RNA"
-
S.Kim , K. Ragunathan , J. Park , C. Joo , D. Kim , and T. Ha “Cooperative conformational transitions keep RecA filament active during ATPase cycle†J. Am. Chem. Soc., 136 (42), pp 14796–14800 (2014) H. Kim, S.C. Abeysirigunawarden, K. Chen, M. Mayerle, K. Ragunathan, Z. Luthey-Schulten, T. Ha , S.A. Woodson, “Protein-guided RNA dynamics during early ribosome assemblyâ€, Nature 506, 334–338 (2014) News and Views: Kathleen B. Hall "Molecular biology: Protein binding cannot subdue a lively RNA"
-
Ragunathan, K., G.Jih and D.Moazed “Epigenetic inheritance uncoupled from sequence specific recruitment†Science 348(6230), 1258699 (2015)
