Lonnie Shea

Biography

Education University of Michigan PhD Chemical Engineering and Scientific Computing ’97 Case Western Reserve University MS Chemical Engineering ’93 BS Chemical Engineering ’92 Positions Held at U-M Professor and William and Valerie Hall Chair, Department of Biomedical Engineering; Professor of Chemical Engineering Postdoctoral Research Fellow, University of Michigan, Departments of Biomedical Engineering and Biologic and Materials Science, 1997 – 1999 Positions Held Elsewhere Professor of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, August 2014 Director, Biotechnology Training Program, Northwestern University, 2008 – 2014 Professor of Chemical and Biological Engineering, Northwestern University, 2008 – 2014 Resident Faculty Member, Institute for BioNanotechnology in Medicine (IBNAM), 2006 – 2014 Associate Professor of Chemical and Biological Engineering, Northwestern University, 2005-2008 Visiting Assistant Professor, M.D. Anderson Cancer Center, Laboratory of Cellular and Tissue Engineering, Charles Patrick, Director, Houston, TX, 2005-2006 Assistant Professor of Chemical and Biological Engineering, Northwestern University, 1999 – 2005 Professional Service NSF Proposal Panel (Mar, 2000, Dec. 2001, Dec. 2002, individual proposals as well) NIH Proposal Review Panels NIDCR, NIDDK, NIBIB, NIAID, NINDS NASA Panel NIH Biotechnology Training Program – Director, September 2008 – present Organizer, Materials Research Society, San Francisco, Spring 2013 Annual Review Biomedical Engineering, Editorial Committee guest member, October 2012 Editorial Board Biotechnology and Bioengineering Molecular Therapy BIOMATTER CRS Drug Delivery and Translational Research Expert Review of Medical Devices

Research Interest

The Shea Lab works at the interface of regenerative medicine, biomaterials, and gene and drug delivery. The central theme for the various projects is creating synthetic environments which can be employed to molecularly dissect tissue formation, both normal or abnormal, or promote regeneration. Of particular emphasis in the lab is: Identifying the fundamental design parameters for delivery of gene therapy vectors from biomaterials. Applying biomaterial and gene / drug delivery technologies to ovarian follicle maturation for infertility, islet transplantation for Type 1 Diabetes, and spinal cord repair for paralysis. Developing strategies for immune tolerance for treating autoimmune disease and enabling allogeneic cell transplantation. Combining a novel dynamic transcription factor activity array with existing systems biology approaches to identify critical factors in cell fate decisions for regenerative medicine, the mechanisms of drug action, the cross talk between cells, and developing therapies for autoimmune disease and cancer. Designing implants to capture metastatic cancer cells for the detection and treatment of metastatic disease at the earliest stages.