Peter Freddolino

Biography

Education Ph.D. in Biophysics and Computational Biology from the University of Illinois at Urbana-Champaign, 2009 B.S. with Honors in Biology from the California Institute of Technology, 2004   Professional History 2011-2014: Postdoctoral research scientist Tavazoie Lab, Department of Systems Biology, Columbia University 2009-2011: Postdoctoral research scientist Tavazoie Lab, Lewis-Sigler Institute for Integrative Genomics, Princeton University  

Research Interest

The regulatory networks of bacteria play a key role in their information processing capabilities, coordinating and executing interactions with their environments. Quantitative, predictive models of these networks would be tremendously beneficial for facilitating the development of new antimicrobial therapies, enabling synthetic biology applications, and understanding bacterial evolution and ecology. Ultimately, the aim of my laboratory is to build a multiscale framework enabling modeling of bacterial regulatory networks at any level of detail, from atomistic to cellular. To this end, we develop and apply high-throughput experimental methods for measuring biomolecular interactions and cellular regulatory states in vivo, and for profiling the phenotypic consequences of regulatory changes. In tandem with these experimental approaches, we use molecular simulation and mathematical modeling to obtain high-resolution insight into the biomolecular interactions driving regulatory networks, and the systems-level effects of altering them.