Amar Natarajan
Professor
Institute for Research in Cancer and Allied Diseases
University of Nebraska Medical Center
United States of America
Biography
Dr. Amar Natarajan is a professor in Institute for Research in Cancer and Allied Diseases
Research Interest
Our research interests are focused on the discovery and development of small molecule inhibitors to perturb disease relevant biomolecules. We are also interested in using these small molecule inhibitors to understand the role of the disease relevant biomolecules in signal transduction. Small molecule inhibitors for these studies are identified and developed from a variety of sources, which include screening chemical libraries, natural products and conformationally constrained mimics. Synthetic chemistry spearheads our research program, however, biology and computational methods are used synergistically in our quest for a better comprehension of the cellular events contiguous to disease relevant proteins.
Publications
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Prakash A, Natarajan A, Marky LA, Ouellette MM, Borgstahl GE. Identification of the DNA-binding domains of human replication protein A that recognize G-quadruplex DNA. Journal of nucleic acids. 2011 May 21;2011.
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Ray D, Nyong AM, Natarajan A. Synthesis of unnatural amino acid derivatives via palladium-catalyzed 1, 4-addition of boronic acids. Tetrahedron letters. 2010 May 12;51(19):2655-6.
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Joseph PR, Yuan Z, Kumar EA, Lokesh GL, Kizhake S, Rajarathnam K, Natarajan A. Structural characterization of BRCT–tetrapeptide binding interactions. Biochemical and biophysical research communications. 2010 Mar 5;393(2):207-10.
