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Daren L Knoell

Professor
Department of Pharmacy Practice
University of Nebraska Medical Center
United States of America

Daren L Knoell

Biography

Dr. Daren L Knoell is a Professor of Pharmacy in the Department of Pharmacy practice, University of Nebraska Medical Center which is located in omaha,Nebraska,United States of America.

Research Interest

Dr. Knoell’s focus of study is to better understand the pathogenesis of lung disease that in turn will reveal new biological insight to prevent or mitigate disease. His laboratory first revealed that zinc and its metabolism, through a family of proteins known as zinc transporters, is critical in preventing lung injury and maintaining host defense against infection. Most recently this line of investigation has focused on zinc metabolism in cell, animal and human studies that has revealed novel insight into zinc coordination over innate immune function through molecular control of integral signaling pathways that impact lung function. Collectively, the major body of this work has resulted in numerous publications in leading journals, continuous NIH-supported research as a PI for over 15 years, international engagement, and several noteworthy awards.

Publications

  • Liu M, Bao S, Napolitano J, Burris D, Yu L, Tridandapani S, Knoell DL. Zinc regulates the acute phase response and serum amyloid A production in response to sepsis through JAK-STAT3 signaling. PLOS One. 2014 9(4):394934.

  • Scordo J, Knoell DL, Torrelles JB. Alveolar epithelial cells in Mycobacterium tuberculosis infection: Active players or innocent bystanders. Journal of Innate Immunity. 2016;8(1):3-14.

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