Luis A. Marky
Professor
Department of Pharmaceutical Sciences
University of Nebraska Medical Center
United States of America
Biography
Dr. Luis A. Marky is a Professor in Department of Pharmaceutical Sciences, College of Pharmacy in University of Nebraska Medical Center which is located in omaha,Nebraska,United States of America.
Research Interest
The research interests of Dr. Marky are in the area of biophysical chemistry and focus on the molecular forces that control the conformational stability and flexibility of nucleic acids, including Okazaki fragments, hairpin loops, intramolecular triplexes, G-quadruplexes, C-quadruplexes, and three- & four-arm DNA junctions and their interaction with drugs. One objective is to improve the delivery of oligonucleotides into cells and drugs, by using natural and synthetic polymers, to block gene expression. His research group is also investigating the role of water on the conformational stability of biomolecules by examining sequence hydration effects in nucleic acids, drug-nucleic acid complexes, DNA covalent adducts, and protein-DNA interactions.
Publications
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Reiling, Calliste and Marky, Luis A. “Contributions of the Loops on the Stability and Targeting of DNA Pseudoknots.†Biochemical Compounds 2,3 (2014).
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Prislan, Iztok; Lee, Hui-Ting.; Lee, Cynthia and Marky, Luis A. “Size of Internal Loop in DNA Hairpins Influences Targeting With Their Partially Complementary Strands†J. Physical Chemistry B. 119(1), 96-104 (2015).
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Reiling, Calliste, Khutsishvili, Irine; Huang, Kai and Marky, Luis A.; “Effect of Loop Length on DNA Pseudoknot Stabilityâ€. J. Physical Chemistry B, 119 (5), 1939–1946 (2015).
