Rongshi Li
Professor
Pharmaceutical Sciences
University of Nebraska Medical Center
United States of America
Biography
Dr. Rongshi Li is an professor of Chemistry and Medicinal Chemistry in Department of Pharmaceutical Sciences, College of Pharmacy in University of Nebraska Medical Center which is located in Omaha, Nebraska, United States of America.
Research Interest
Dr. Rongshi Li Research interest is Fragment-based and structure-guided design of enzyme inhibitors and disruptors of protein-protein interactions; synthesis of natural products and their derivatives for drug discovery; hit-to-lead and lead optimization using organic/medicinal chemistry; drug design and development in anticancer and antibiotic therapeutics.
Publications
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Neidhart DJ, Howell PL, Petsko GA, Powers VM, Li R, Kenyon GL, Gerlt JA. Mechanism of the reaction catalyzed by mandelate racemase. 2. Crystal structure of mandelate racemase at 2.5-. ANG. resolution: identification of the active site and possible catalytic residues. Biochemistry. 1991 Sep;30(38):9264-73.
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Li R, Chen X, Gong B, Selzer PM, Li Z, Davidson E, Kurzban G, Miller RE, Nuzum EO, McKerrow JH, Fletterick RJ. Structure-based design of parasitic protease inhibitors. Bioorganic & medicinal chemistry. 1996 Sep 30;4(9):1421-7.
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Zhou H, Wu S, Zhai S, Liu A, Sun Y, Li R, Zhang Y, Ekins S, Swaan PW, Fang B, Zhang B. Design, synthesis, cytoselective toxicity, structure–activity relationships, and pharmacophore of thiazolidinone derivatives targeting drug-resistant lung cancer cells. Journal of medicinal chemistry. 2008 Feb 8;51(5):1242-51.
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Li R, Kenyon GL, Cohen FE, Chen X, Gong B, Dominguez JN, Davidson E, Kurzban G, Miller RE, Nuzum EO, Rosenthal PJ. In vitro antimalarial activity of chalcones and their derivatives. Journal of medicinal chemistry. 1995 Dec;38(26):5031-7.
