Franklyn F Bolander Jr

Biography

Dr. Franklyn F. Bolander, Jr. is currently working as an Associate Professor in the  Department of Biology, University of South Carolina , United States of America. His research interests includes Biological sciences. He is serving as an editorial member and reviewer of several international reputed journals. Dr. Franklyn F. Bolander, Jr. is the member of many international affiliations. He has successfully completed his Administrative responsibilities. He has authored of many research articles/books related to Biological sciences.

Research Interest

Dr. Bolander's primary research interests involve the molecular mechanisms of prolactin action and its regulation of growth and differentiation. His model system is the mouse mammary gland. Prolactin is a member of the cytokine family, which uses the Jak/Stat pathway to stimulate differentiation, as measured by milk protein induction. Recently, his laboratory has shown that prolactin can also activate the nitric oxide (NO)/cGMP pathway, which mediates growth and blocks differentiation. He is currently investigating the molecular mechanisms by which prolactin activates NO synthase and by which NO/cGMP acts as a switch between growth and differentiation. Since prolactin is an autocrine factor in breast cancer, a better understanding of this growth/differentiation balance may permit pharmacological therapy to switch the tumor cells from growth to differentiation. Previous research projects have included the regulation of hormone receptors (both membrane and nuclear), other second messengers, transcription and translation of both milk proteins and the mouse mammary tumor virus (MMTV), hormonally induced modification of chromatin proteins, and characterization of epithelial cell-MMTV interactions.