Department of Biological Sciences
University of South Carolina
United States of America
Dr. Katie Kathrein is currently working as an Assistant Professor in the Department of Biology, University of South Carolina, United States of America. His research interest includes Biological sciences. She is serving as an editorial member and reviewer of several international reputed journals. Dr. Katie Kathrein is the member of many international affiliations. She has successfully completed her Administrative responsibilities. She has authored of many research articles/books related to Biological sciences.
The primary focus of the Kathrein lab is to understand how chromatin modifying factors establish a code for HSC gene regulation to direct both stem cell maintenance and differentiation. We are seeking to identify novel chromatin remodeling complexes that regulate the hematopoietic stem cells using the Zebrafish as a model system. The Zebrafish is an ideal model for exploring the establishment of HSCs for many reasons. The process of hematopoiesis is well conserved between humans and the zebrafish and the formation of the very first HSCs can be visualized at 36 hours post fertilization (hpf). The genetic malleability of the embryos make manipulation of hematopoiesis possible at all different stages. Through these studies, we will achieve a better understanding of HSCs to improve stem cell function for hematopoietic stem cell transplants. As well, we hope to expose chromatin remodeling enzymes that function abnormally in cancer as targets for new chemotherapy treatments.
Kathrein KL, Chari S, Winandy S. Ikaros Directly Represses the Notch Target Gene Hes1 in a Leukemia T Cell Line IMPLICATIONS FOR CD4 REGULATION. Journal of Biological Chemistry. 2008 Apr 18;283(16):10476-84.
Mochida GH, Ganesh VS, De Michelena MI, Dias H, Atabay KD, Kathrein KL, Huang HT, Hill RS, Felie JM, Rakiec D, Gleason D. CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. Nature genetics. 2012 Nov 1;44(11):1260-4.
McKinney-Freeman S, Cahan P, Li H, Lacadie SA, Huang HT, Curran M, Loewer S, Naveiras O, Kathrein KL, Konantz M, Langdon EM. The transcriptional landscape of hematopoietic stem cell ontogeny. Cell stem cell. 2012 Nov 2;11(5):701-14.