Department of Biological Sciences
University of South Carolina
United States of America
Dr. Rekha Patel is currently working as a Professor in the Department of Biology, University of South Carolina, United States of America. Her research interests include Biological sciences. She is serving as an editorial member and reviewer of several international reputed journals. Dr. Rekha Patel is the member of many international affiliations. She has successfully completed her Administrative responsibilities. She has authored of many research articles/books related to Biological sciences.
Our research focuses on regulation of cell survival and apoptosis by interferon-induced, double-stranded RNA activated protein kinase PKR. In particular, we study the regulation of PKR’s kinase activity by its activator protein PACT (DYT16) in response to stress signals that include oxidative stress, growth factor withdrawal, and endoplasmic reticulum (ER) stress. Our work has major implications on origin, progression, and treatment of many human diseases and disorders such as cancer, neurodegeneration, diabetes, and aging.In addition to this, in collaboration with the Dudycha lab, we are currently investigating stress response and its effects on aging and longevity using the microcrustacean Daphnia as a model system. We focus on heat shock response, eIF2 alpha phosphorylation, and its relationship to life span determination.
Schumpert CA, Dudycha JL, Patel RC. Development of an efficient RNA interference method by feeding for the microcrustacean Daphnia. BMC biotechnology. 2015 Oct 7;15(1):91.
Schumpert CA, Anderson C, Dudycha JL, Patel RC. Involvement of Daphnia pulicaria Sir2 in regulating stress response and lifespan. Aging (Albany NY). 2016 Feb;8(2):402.
Chukwurah E, Handy I, Patel RC. ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element. Biochemical Journal. 2017 Apr 1;474(7):1241-57.