Department of Biological Sciences
University of South Carolina
United States of America
Dr. Vicki Vance is currently working as a Professor in the Department of, University of South Carolina, United States of America. Her research interests include Biological sciences. She is serving as an editorial member and reviewer of several international reputed journals. Dr. Vicki Vance is the member of many international affiliations. She has successfully completed her Administrative responsibilities. She has authored of many research articles/books related to Biological sciences.
The possibility that small RNAs ingested from plant-based foods could have biological effects in humans and other mammals is currently an issue of considerable interest. It has long been known that ingested RNA from food sources is taken up by the digestive system in nematodes and insects and can control the expression of genes in those organisms. A recent report has raised the interesting possibility that a similar phenomenon occurs in humans and other mammals. This work has generated excitement because it raises the possibility of bioengineering edible plants to produce therapeutic miRNAs that could then be delivered to affected tissues by ingestion. However, it has also generated controversy, and several groups have challenged the finding. We addressed this controversy in an experiment designed to both detect a therapeutic effect of ingested miRNAs and to demonstrate their uptake in a mouse model for colon cancer. Our results indicate that tumor suppressor miRNAs designed to mimic small RNAs produced in plants were taken up by the digestive tract of ApcMin/+ mice upon ingestion, as evidenced by their higher concentration in the miRNA-treated animals. Furthermore, the ingested miRNAs were functional, as evidenced by the reduction in tumor burden in the treated mice. These results support the original finding that endogenous plant miRNAs are taken up by the mammalian digestive tract and can function to target mammalian genes, raising the intriguing prospect of using edible plants engineered to produce mammalian tumor suppressor miRNAs as an effective, nontoxic, and inexpensive chemopreventive strategy in humans.
Mlotshwa S, Pruss GJ, Gao Z, Mgutshini NL, Li J, Chen X, Bowman LH, Vance V. Transcriptional silencing induced by Arabidopsis T‐DNA mutants is associated with 35S promoter siRNAs and requires genes involved in siRNA‐mediated chromatin silencing. The Plant Journal. 2010 Nov 1;64(4):699-704.
Bowman LH, Johnson C, Pruss G, Vance V. Phased Small RNAs in Rice. InNon Coding RNAs in Plants 2011 (pp. 107-119). Springer Berlin Heidelberg.
Foreman AW, Pruss GJ, Vance V. Plant‐Virus Interaction: Defense and Counter‐Defense. Molecular Plant Immunity. 2012 Oct 10:169-85.