Pharmacology and Pharmaceutical Sciences
University of Southern California
United States of America
Jianming Xie was born and raised in Putian, China. He received the B.S. degree in Chemistry with highest honors from Fudan University, Shanghai, China, in 1997, and the M.S. degree in Organic Chemistry from Shanghai Institute of Organic Chemistry (SIOC), China, in 2000. In his M.S. research in the laboratory of Prof. Yongzheng Hui and Prof. Biao Yu, he completed the synthesis of a complex natural glycoside using a one-pot four-glycosylation method. He later switched his interest to Chemical Biology, and moved to the United States in 2001 to pursue a Ph.D. degree under the guidance of Prof. Peter Schultz at the Scripps Research Institute, La Jolla, California. His postdoctoral research integrated the method of site-specific protein modification with fluorescence microscopy and flow cytometry for the study of antigen recognition by T cells. This work revealed ligand-dependent transport of T cell receptors to the immunological synapse, and also led to the development of a protein photochemistry approach to isolate rare antigen-specific T cells from patient blood samples. In December 2014, he started his lab in the Department of Pharmacology and Pharmaceutical Sciences at the University of Southern California (USC) School of Pharmacy. His lab combines synthetic peptide chemistry, protein design, cellular engineering, and fluorescence microscopy in order to interrogate, engineer, and enhance the specificity and efficiency of T cell antigen recognition. The long-term goal is to use the obtained knowledge to guide the design of enhanced immunotherapy and vaccines against cancer, infection, and autoimmune diseases.
Chemical biology, T-Cell Immunology, Immunotherapy for Cancer, HIV and Autoimmune Diseases
Wang J, Xie J, Schultz PG. A genetically encoded fluorescent amino acid. Journal of the American Chemical Society. 2006 Jul 12;128(27):8738-9.
Xie J, Schultz PG. A chemical toolkit for proteins—an expanded genetic code. Nature Reviews Molecular Cell Biology. 2006 Oct 1;7(10).
Wang L, Xie J, Schultz PG. Expanding the genetic code. Annu. Rev. Biophys. Biomol. Struct.. 2006 Jun 9;35:225-49.