John W. Tomsho
Chemistry and Biochemistry
University of the Sciences
United States of America
The development of new agents for the study and treatment of diseases is being pursued utilizing tools from the fields of chemistry and biology. The research in my group is currently focused on the development of small molecules and peptides that target important processes in the organisms that cause infectious diseases. This goal is being pursued via two major research directions that reflect the areas of chemistry and biology and their interface. First is the use of boronic acid-containing compounds as potential small molecule pharmaceutical agents. Second is the development of new techniques for the generation of peptide libraries and the subsequent selection of active members that disrupt specific protein-protein interactions.
"Developing new pharmaceutical agents for the treatment of diseases such as viral or bacterial infections and cancer Expanding the use of boronic acids as pharmaceutical agents Developing peptides for the disruption of protein-protein interactions"
Tomsho JW, Benkovic SJ. Elucidation of the mechanism of the reaction between phenylboronic acid and a model diol, Alizarin Red S. The Journal of organic chemistry. 2012 Jan 13;77(5):2098-106.
Tomsho JW, Benkovic SJ. Examination of the reactivity between benzoxaborole and related compounds with a cis-diol. InABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 2012 Aug 19 (Vol. 244). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
Liu CT, Tomsho JW, Benkovic SJ. The unique chemistry of benzoxaboroles: current and emerging applications in biotechnology and therapeutic treatments. Bioorganic & medicinal chemistry. 2014 Aug 15;22(16):4462-73.