University of the Sciences
United States of America
My research has uncovered a class of compounds with significant anti-AIDS activity. Using medicinal chemical principles I am trying to design and synthesize more active members in this family. One example of these novel drugs, NCI-667951, or 2-(2-nitrophenylsulfonyl)-N, 4-dimethylaniline, is shown. Other research involves the large-scale synthesis of a key intermediate of adriamycin, a naturally occurring anti-cancer agent. However, it should be noted that as a result of my recent appointment as an Emeritus Professor, effective in Fall 2002, I will not be accepting any new research students into my laboratory. I will continue to direct the graduate students currently working in my laboratory, and will continue to be available for consultation in my areas of expertise.
"Organic syntheses, Medicinal chemistry, Proton NMR"
Smith IV RE, McKee JR, Zanger M. The electrophilic bromination of toluene: Determination of the ortho, meta, and para ratios by quantitative FTIR spectrometry. J. Chem. Educ. 2002 Feb 1;79(2):227.
Zanger M, Moyna G. Measurement of the Isotopic Ratio of 10B/11B in NaBH4 by 1H NMR. J. Chem. Educ. 2005 Sep 1;82(9):1390.
Ren H, Zanger M, McKee JR. Synthesis of tetrahydrobenzazepinesulfonamides and their rearrangement to diarylsulfones. Synthetic communications. 2006 Jan 1;36(3):355-63.