Zachary A. Klase
Assistant Professor of Biological Sciences
Biological Sciences
University of the Sciences
United States of America
Biography
My lab focuses on the study of the Human Immunodeficiency Virus (HIV) the causative agent of Acquired Immunodeficiency Syndrome (AIDS). HIV presents an interesting challenge for two reasons: 1) the virus integrates into the genome of the host cell and can persist for decades, 2) the viral genome is relatively small thus requiring the virus to co-opt various cellular processes to be successful. Of particular interest to me are the mechanisms that control viral replication and allow the virus to persist in the presence of therapy. My work combines molecular biology and immunology practices to examine the interface between host and pathogen.
Research Interest
"Human Immunodeficiency Virus, RNA interference, Immune response to viral infections"
Publications
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Klase Z, Houzet L, Jeang KT. Replication competent HIV-1 viruses that express intragenomic microRNA reveal discrete RNA-interference mechanisms that affect viral replication. Cell & bioscience. 2011 Nov 23;1(1):38.
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Coley W, Van Duyne R, Carpio L, Guendel I, Kehn-Hall K, Chevalier S, Narayanan A, Luu T, Lee N, Klase Z, Kashanchi F. Absence of DICER in monocytes and its regulation by HIV-1. Journal of Biological Chemistry. 2010 Oct 15;285(42):31930-43.
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Zhou M, Huang K, Jung KJ, Cho WK, Klase Z, Kashanchi F, Pise-Masison CA, Brady JN. Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29. Journal of virology. 2009 Jan 15;83(2):1036-44.
