Biochemistry Experts

Zhihong Wang

Assistant Professor
Chemistry and Biochemistry
University of the Sciences
United States of America


Protein phosphorylation, catalyzed by kinases, is the most universal mechanism of regulating protein function and transmitting signals throughout the cell. Aberrant activation of kinases causes dysfunction of cell signaling and regulatory pathways, resulting in numerous human diseases including cancer. Our laboratory is interested in the molecular logic of kinase function under normal and pathological conditions. By integrating techniques from biochemistry, proteomics, molecular biology, and cell biology, we currently study the molecular mechanism of BRAF activation, regulation, and oncogenesis. The long-term goal of our research is to enhance our biochemical understanding of the origin of cancer and to provide a better molecular basis for drug development.

Research Interest

"Illuminating the molecular mechanisms of aberrant activation of oncogenic kinases Dissecting the affected signaling pathways where oncogenic kinases lie in Examining the effects of posttranslational modification on enzyme activity and its physiological role"


  • Wang Z, Longo PA, Tarrant MK, Kim K, Head S, Leahy DJ, Cole PA. Mechanistic insights into the activation of oncogenic forms of EGF receptor. Nature structural & molecular biology. 2011 Dec 1;18(12):1388-93.

  • Wang Z, Raines LL, Hooy RM, Roberson H, Leahy DJ, Cole PA. Tyrosine phosphorylation of mig6 reduces its inhibition of the epidermal growth factor receptor. ACS chemical biology. 2013 Sep 6;8(11):2372-6.

  • Wang Z, Cole PA. Catalytic mechanisms and regulation of protein kinases. Methods in enzymology. 2014;548:1.

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