George Osol
Professor
Department of Obstetrics, Gynecology and Reproductive Scienc
University of Vermont
United States of America
Biography
Prof George Osol received his Ph.D.University of Vermont, Burlington, VT, Reproductive Physiology. Currently, he is working as Professor in university of vermont. He has successfully completed his Administrative responsibilities as Professor. His research has included interest is vascular adaptation during pregnancy, and addresses the following questions: (1) What are the mechanisms that regulate maternal uterine vascular remodeling during pregnancy, and how are they altered in hypertensive pregnancy? (2) What is the role of PlGF and VEGF in mediating these processes? (3) How do physical forces such as intravascular pressure/stretch regulate resistance artery tone (myogenic behavior)? (4) What is the nature of communication/signal transfer between veins and arteries (venoarterial signaling)? The rat is the primary animal model, and some of the experimental techniques used in the lab include: in vivo surgical manipulation of the uterus and its circulation; in vivo inhibition of cell signaling (e.g. NOS inhibition, ACE inhibition, calcium channel blockade); isolated pressurized vessel myography of resistance arteries and veins; molecular analyses (RT-PCR, Western blotting, immunocytochemistry); tissue/cell imaging for morphometric analysis, e.g. TEM, SEM, confocal microscopy.
Research Interest
Dr. Osol’s research interest is vascular adaptation during pregnancy, and addresses the following questions: (1) What are the mechanisms that regulate maternal uterine vascular remodeling during pregnancy, and how are they altered in hypertensive pregnancy? (2) What is the role of PlGF and VEGF in mediating these processes? (3) How do physical forces such as intravascular pressure/stretch regulate resistance artery tone (myogenic behavior)? (4) What is the nature of communication/signal transfer between veins and arteries (venoarterial signaling)? The rat is the primary animal model, and some of the experimental techniques used in the lab include: in vivo surgical manipulation of the uterus and its circulation; in vivo inhibition of cell signaling (e.g. NOS inhibition, ACE inhibition, calcium channel blockade); isolated pressurized vessel myography of resistance arteries and veins; molecular analyses (RT-PCR, Western blotting, immunocytochemistry); tissue/cell imaging for morphometric analysis, e.g. TEM, SEM, confocal microsc
Publications
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CIPOLLA MJ, GOKINA NI, OSOL G. Pressure-induced actin polymerization in vascular smooth muscle as a mechanism underlying myogenic behavior. The FASEB Journal. 2002 Jan 1;16(1):72-6.
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Osol GE, Halpern WI. Myogenic properties of cerebral blood vessels from normotensive and hypertensive rats. American Journal of Physiology-Heart and Circulatory Physiology. 1985 Nov 1;249(5):H914-21.
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Halpern W, Osol G, Coy GS. Mechanical behavior of pressurized in vitro prearteriolar vessels determined with a video system. Annals of biomedical engineering. 1984 Sep 1;12(5):463-79.
