Charles J Sih
Professor Emeritus
Professor Pharmaceutical Sciences Division
UNIVERSITY OF WISCONSIN - MADISON
United States of America
Biography
Charles (Professor, Pharmaceutical Sciences and Department of Chemistry) received his AB-Biology from Carroll College, MS degree in bacteriology from Montana State University in 1955, and his PhD in microbiology from the University of Wisconsin in 1958. He then joined the Squibb Institute for Medical Research as a senior microbial biochemist before returning to Wisconsin in 1960. His research interests include enzymatic catalyses to prepare enantiomerically-pure compounds; total synthesis of natural products; biosynthesis of vancomycin; and enzymatic mechanism of thyroxine biosynthesis. Professional Interests: Enzymatic catalyses to prepare enantiomerically-pure compounds; total synthesis of natural products; biosynthesis of vancomycin; and enzymatic mechanism of thyroxine biosynthesis
Research Interest
Professional Interests: Enzymatic catalyses to prepare enantiomerically-pure compounds; total synthesis of natural products; biosynthesis of vancomycin; and enzymatic mechanism of thyroxine biosynthesis
Publications
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Z.W. Guo, G.M. Salamonczyk, K. Han, K. Machiya and C.J. Sih, "Enzymatic oxidative phenolic coupling," J. Org. Chem., 62, 6700 (1997).
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C.J. Sih, "Chemoenzymatic synthesis of the side chain of taxol," in Enantioselective Synthesis of b-Amino Acids, E. Juaristi (ed.), Wiley-VCH, New York, p. 433, 1997.
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G.M. Salamonczyk, K. Han, Z.W. Guo and C.J. Sih, "Total synthesis of cryptophycins via a chemoenzymatic approach," J. Org. Chem., 61, 6893 (1996).
