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Steven M Swanson

Dean
Professor Pharmaceutical Sciences Division
UNIVERSITY OF WISCONSIN - MADISON
United States of America

Biography

Dr. Swanson earned his doctorate in Pharmacognosy at the University of Illinois at Chicago. Dr. Swanson’s graduate work focused on the ability of retinoids to modulate carcinogen metabolism and binding to nuclear macromolecules such as DNA. He studied tumor biology and hormonal modulation of mammary carcinogenesis with Satyabrata Nandi in the Cancer Research Laboratory at the University of California, Berkeley. For three years, Dr. Swanson served on the faculty of the University of Alabama at Birmingham where he used animal model systems to elucidate the cellular mechanisms by which dietary substances modulate carcinogenesis. In 1998, he was recruited back to UIC as an assistant professor where his research has focused on two areas: the discovery of anticancer drugs from natural sources and understanding the role of hormones, particularly growth hormone, in cancer. His research programs have been continuously funded by federal agencies for the past 19 years and he has published over 100 peer-reviewed articles, review articles and book chapters. Dr. Swanson’s academic leadership positions have included Director of Graduate Studies in Pharmacognosy, Assistant to the Director of the Research Resources Center of the University of Illinois at Chicago, Interim Leader of the Experimental Therapeutics Program of the UIC Cancer Center, Associate Dean for Research and Graduate Education, Visiting Vice Dean and Acting Dean of the College of Pharmacy. He has also served as a Member of the National Institutes of Health Chemo-Dietary Prevention Study Section and as a Scientific Reviewer for the Department of Defense Congressionally Directed Medical Research Programs in prostate and breast cancer. Dr. Swanson is a member of the advisory board of Endocrinology and Associate Editor of the Journal of Natural Products. In July of 2014, Dr. Swanson became the Dean of the School of Pharmacy at the University of Wisconsin-Madison.

Research Interest

Preclinical model systems to investigate the role of the growth hormone/IGF-I axis in prostate carcinogenesis. Molecular & cellular based screens for the discovery of novel anticancer agents from natural substances Elucidation of molecular mechanisms of active compounds Mouse-based studies of preclinical efficiency.

Publications

  • Acuña UM, Matthew S, Pan L, Kinghorn AD, Swanson SM, Carcache de Blanco EJ. Apoptosis Induction by 13-Acetoxyrolandrolide through the Mitochondrial Intrinsic Pathway. Phytother Res. 2013 Dec 12. doi: 10.1002/ptr.5091. [Epub ahead of print] PubMed PMID: 24338805.

  • Ren Y, Lantvit DD, Deng Y, Kanagasabai R, Gallucci JC, Ninh TN, Chai HB, Soejarto DD, Fuchs JR, Yalowich JC, Yu J, Swanson SM, Kinghorn AD. Potent Cytotoxic Arylnaphthalene Lignan Lactones from Phyllanthus poilanei. J Nat Prod. 2014 Jun 27;77(6):1494-504. doi: 10.1021/np5002785. Epub 2014 Jun 12. PubMed PMID: 24937209.

  • VanderMolen KM, Darveaux BA, Chen WL, Swanson SM, Pearce CJ, Oberlies NH. Epigenetic Manipulation of a Filamentous Fungus by the Proteasome-Inhibitor Bortezomib Induces the Production of an Additional Secondary Metabolite. RSC Adv. 2014 Jan 1;4(35):18329-18335. PubMed PMID: 24955237.

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