William S Mellon
Senior Associate Dean, Ac. Affairs
Pharmaceutical Sciences Division
UNIVERSITY OF WISCONSIN - MADISON
United States of America
Biography
William received his BS degree (1969) in pharmacy from Northeastern University and his PhD degree (1976) in pharmacology from The Ohio State University. He was an NIH Postdoctoral Fellow at the Department of Biochemistry, U.W.-Madison before joining the School of Pharmacy faculty in 1979. His research interests include the biochemical pharmacology of hormone action, with particular emphasis on receptor dynamics and their transcriptional and posttranscriptional regulation of target genes to understand the molecular mechanism of hormone action. A correlative area of investigation involves the elucidation of cellular differentiation of hematopoietic and immune cells induced by sterol hormones and peptides. He is a member of the American Society of Biochemistry and Molecular Biology and the Endocrine Society.
Research Interest
Professional Interests: Biochemical pharmacology of hormone action, with particular emphasis on receptor dynamics and their transcriptional and posttranscriptional regulation of target genes to understand the molecular mechanism of hormone action
Publications
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M. Moss, E.R. Palmer, P. Kuzmic, B.E. Dunlap, W. Henzel, J. Kofron, C. Royer, W.S. Mellon and D.H. Rich, "Identification of actin and HSP70 as cyclosporin A binding proteins by photoaffinity labelling and fluorescent displacement assays," J. Biol. Chem., 267, 22054-22059 (1992).
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R. Mosavin and W.S. Mellon, "Posttranscriptional regulation of osteocalcin mRNA in clonal osteoblast cells by 1,25-dihydroxyvitamin D3," Arch. Biochem. and Biophys., 332, 142-152 (1996).
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M.A. Rivera-Bermúdez and W.S. Mellon, "1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] translocates PKCa but not PKCb1, PKCe or PKCz to the nuclei in ROS 17/2.8 cells," Endocrinology, abstract #P1-601 (1998).
