Caroline M. Alexander
PROFESSOR
Department of Oncology
University of Wisconsin-Madison
United States of America
Biography
Professor of Oncology Developmental Therapeutics - UW Carbone Cancer Center Mammary Stem Cells Mouse Models Breast Cancer Cell Signaling B.Sc., 1982, Biochemistry, University of Aberdeen, Scotland Ph.D., 1985, Cell Biology and Biochemistry, University of Kent, England Postdoctoral research: Imperial Cancer Research Fund, London and UC-San Francisco Current projects include: The discovery of the molecular and cellular mechanism that underlies the tumor resistance phenotype illustrated by mice with a mutation in the heparan sulfate proteoglycan, syndecan-1 (Sdc1) (McDermott et al 2006). Modeling of stem cell-based breast cancer The activation of stromal cells and their recruitment to tumor development during Wnt-induced tumorigenesis The analysis of adult stem cell responses during tumor initiation Determination of how Wnt signaling supports normal mammary stem cell function
Research Interest
aspects of mammary gland biology and neoplasia using transgenic mouse models.
Publications
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Sikora MJ, Jacobsen BM, Levine K, Chen J, Davidson NE, Lee AV, Alexander CM, Oesterreich S. WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines. Breast Cancer Res. 2016 Sep 20;18(1):92. doi: 10.1186/s13058-016-0748-7.
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Kasza I, Hernando D, Roldan-Alzate A, Alexander CM, Reeder SB. Thermogenic profiling using magnetic resonance imaging of dermal and other adipose tissues. JCI Insight. 2016 Aug 18;1(13):e87146.
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Chin EN, Martin JA, Kim S, Fakhraldeen SA, Alexander CM. Lrp5 Has a Wnt-Independent Role in Glucose Uptake and Growth for Mammary Epithelial Cells. Mol Cell Biol. 2016 Dec 28(2015);36(6):871-85.
