Christopher A. Bradfield
PROFESSOR
Department of Oncology
University of Wisconsin-Madison
United States of America
Biography
Professor of Oncology Genetics Program Member - UW Carbone Cancer Center Molecular Clocks Environmental Toxins PAS Proteins B.Sc., 1982, Environmental Toxicology, University of California at Davis Ph.D., 1986, Toxicology/Nutrition, University of California at Berkeley Postdoctoral research: McArdle Laboratory, University of Wisconsin-Madison Their laboratory is interested in a family of transcriptional regulators known as PAS proteins. Members of this emerging family of proteins control a number of processes, including xenobiotic metabolism (Ah-receptor and Arnt), circadian rhythms (Per), angiogenesis (HIF1a and Arnt), and neurogenesis (Sim). The model system that is currently emphasized is the signal transduction pathway mediated by Ah-receptor/Arnt heterodimeric complex.
Research Interest
signal transduction pathway mediated by Ah-receptor/Arnt heterodimeric complex.
Publications
-
DÃaz-DÃaz CJ, Ronnekleiv-Kelly SM, Nukaya M, Geiger PG, Balbo S, Dator R, Megna BW, Carney PR, Bradfield CA, Kennedy GD. The Aryl Hydrocarbon Receptor is a Repressor of Inflammation-associated Colorectal Tumorigenesis in Mouse. Ann Surg. 2016 Sep;264(3):429-36.
-
Vaidyanathan B, Chaudhry A, Yewdell WT, Angeletti D, Yen WF, Wheatley AK, Bradfield CA, McDermott AB, Yewdell JW, Rudensky AY, Chaudhuri J. The aryl hydrocarbon receptor controls cell-fate decisions in B cells. J Exp Med. 2017
-
Seok SH, Lee W, Jiang L, Molugu K, Zheng A, Li Y, Park S, Bradfield CA, Xing Y. Structural hierarchy controlling dimerization and target DNA recognition in the AHR transcriptional complex. Proc Natl Acad Sci U S A. 2017 May
