Jiaoyang Jiang
Assistant Professor
Department of Pharmacy
University of Wisconsin-Madison
United States of America
Biography
Dr. Jiaoyang Jiang, an Assistant Professor of Drug Discovery at UW-Madison School of Pharmacy, began her appointment in August 2013 after completing her postdoctoral research at Harvard Medical School in the laboratory of Suzanne Walker. During her postdoctoral research, she characterized the glycosyltransferase & the unique proteolytic activities of human O-GlcNAc transferase (OGT), and discovered a small molecule with novel mechanism of inhibition. She earned her PhD in chemistry from Brown University with David Cane, where she elucidated natural product biosynthetic pathways in bacteria. Education: Postdoc Chemical Biology - Harvard Medical School, 2013 PhD Chemistry - Brown University, 2009 BS Chemistry - Univ. of Science & Technology of China, 2004
Research Interest
roles of protein posttranslational modifications in the complexity of epigenetic regulation.
Publications
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Li B#, Li H#, Hu CW, Jiang J*. Structural insights into the substrate binding adaptability and specificity of human O-GlcNAcase. Nature Communications (2017) 8:666. doi: 10.1038/s41467-017-00865-1. (#equal contribution)
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Liu F, Ma F, Wang Y, Hao L, Zeng H, Jia C, Wang Y, Liu P, Ong IM, Li B, Chen G, Jiang J, Gong S, Li L, Xu W. PKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis. Nature Cell Biology (Advance Online Publication, DOI: 10.1038/ncb3630)
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Hu CW#, Worth M#, Fan D#, Li B#, Li H#, Lu L, Zhong X, Lin Z, Wei L, Ge Y, Li L, Jiang J*. Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase. Nature Chemical Biology (Advance Online Publication, DOI: 10.1038/nchembio.2494) (#equal contribution)
