David A. Brown
Department of Human Nutrition, Foods, and Exercise
Virginia Tech University
United States of America
Biography
Brown directs a laboratory that combines disciplines in cardiac physiology and mitochondrial biology. Development of novel therapeutics to improve mitochondrial function is a major focus of his research program. Brown’s research is supported by several extramural grants, and he has presented his work all over the world. He is a member of the American Heart Association, American Physiological Society, and Mitochondrial Physiology Society. He serves as a reviewer for numerous grant agencies and scientific journals.
Research Interest
cardiac physiology and mitochondrial biology
Publications
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Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart. Shi J, Dai W, Hale SL, Brown DA, Wang M, Han X, Kloner RA.Life sciences. 2015; 141:170-8.
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Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics. Alleman RJ, Tsang AM, Ryan TE, Patteson DJ, McClung JM, Spangenburg EE, Shaikh SR, Neufer PD, Brown DA. American journal of physiology. Heart and circulatory physiology. 2016; 310(10):H1360-70.
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Mitochondrial function as a therapeutic target in heart failure. David A. Brown, Justin B. Perry, Mitchell E. Allen, Hani N. Sabbah, Brian L. Stauffer, Saame Raza Shaikh, John G.F. Cleland, Wilson S. Colucci, Javed Butler, Adriaan A. Voors, Stefan D. Anker, Bertram Pitt, Burkert Pieske, Gerasimos Fillipatos, Stephen J. Greene, and Mihai Gheorghiade.Nature Reviews Cardiology 2017 (PMID 28004807)
