Sreenivasa R Chinni
Urology and Pathology
Wayne State University
United States of America
Sreenivasa R Chinni is an Associate Professor in the Department of Urology and Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University, USA.
Prostate cancer, chromosomal alterations, chemokine and chemokine receptors, and cell signaling and metastasis. Molecular mechanism of prostate cancer metastasis. Currently, the Chinni laboratory is studying the role of chemokines and chemokine receptors in tumor cell invasion and metastasis using in vitro and in vivo preclinical models of metastasis. Dr. Chinni recently found that chemokine receptor CXCR4 highly localizes to lipid rich membrane microdomains, activate members of growth factor family receptors and down stream signaling pathways. In tumor cells this transactivation pathway further contributes to intraosseous tumor growth of prostate cancer cells. Other project in the lab is to define molecular targets of recently identified recurrent chromosomal alterations in prostate cancer patients. The Chinni laboratory subsequently identified that androgen activation of common chromosomal translocations, TMPRSS2-ERG induce CXCR4 transcription, and thereby contributing to enhanced invasion and metastasis of prostate cancer cells. Dr. Chinni and colleagues are currently characterizing the functional significance of chromosomal translocations and chemokine receptor expression in prostate cancer metastasis.