Peter A Goldstein
Weill Cornell Medical College
United States of America
Peter A Goldstein,Professor of Anesthesiology Molecular and cellular effects of general anesthetics The overall focus of the lab is to better define the mechanisms by which a diverse group of pharmacological agents produce anesthesia. A potentially important region within the central nervous system (CNS) for contributing to the anesthetized state is the thalamus; it is a critical relay site for sensory information and it is considered to be an essential structure in the generation of consciousness and sleep. Inhibitory synaptic transmission helps regulate thalamic function, and the GABAA receptor is the primary receptor for mediating such transmission within the CNS. Many anesthetics are known to modulate the function of this receptor. This raises a number of basic questions, such as: What are the effects of different anesthetics on synaptic transmission in the thalamus? Do these drugs have unique effects in specific thalamic regions as a function of differences in receptor expression? GABA release is controlled by multiple mechanisms, including a variety of ion channels; is the function of those channels altered in the presence of anesthetics? The lab uses electrophysiological, immunohistochemical, and molecular biological techniques to address those issues.
Directing the Timing of Maturation in Human Pluripotent Stem Cell-Derived Neurons awarded by Tri-Institutional Stem Cell Initiative Principal Investigator 2016 - 2018
Functional Connectivity under Optogenetic Control Allows Modeling of Human Neuromuscular Disease. Cell Stem Cell. 2016
Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain?. Trends in Pharmacological Sciences.
Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability. Neurobiology of disease. 2016