Maxim Sokolov
Associate Professor
Centers for Neuroscience,Ophthalmology
West Virginia University Health Science Center
United States of America
Biography
This laboratory studies biochemistry and cell biology of photoreceptors, sensory neurons of the retina responsible for acquisition of visual information. Our primary research interest is to elucidate molecular and cellular functions of chaperonin CCT/TRiC in neurons using mouse photoreceptors as a model. Our long-term goal is to explore the link between the protein-folding activity of CCT/TRiC complex and pathological neurodegenerative processes in the retina and brain caused by perturbation of protein homeostasis. In our studies we utilize variety of techniques including transgenic gene manipulation, global and targeted analyses of genes and proteins expression, and fluorescent microscopy. Our vision research laboratories are located on the 3d floor of WVU Eye Institute. We accept and train students from the Neuroscience and Biochemistry and Molecular Biology graduate programs.
Research Interest
Interested in Centers for Neuroscience,Ophthalmology
Publications
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Sinha S, Majumder A, Belcastro M, Sokolov M, Artemyev NO. Expression and subcellular distribution of UNC119a, a protein partner of transducin α subunit in rod photoreceptors. Cell Signal (2013 Jan) 25(1): 341-8. doi: 10.1016/j.cellsig.2012.10.005.
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Gao X, Sinha S, Belcastro M, Woodard C, Ramamurthy V, Stoilov P, Sokolov M. Splice isoforms of phosducin-like protein control the expression of heterotrimeric G proteins. J Biol Chem (2013 Sep 6); 288(36):25760-8.
