Michael R. Gunther
West Virginia University Health Science Center
United States of America
Works as Professor in Biochemistry
Dr. Gunther's research has been directed towards understanding how mutant forms of the protein superoxide dismutase cause the neurodegenerative disease amyotrophic lateral sclerosis (ALS). The primary interests of the lab have been identifying and characterizing free radicals formed on proteins with the hope of understanding how these unstable species might contribute to disease pathophysiology. In recent years we have been studying mitochondrial defects that arise from the expression of the ALS-causing mutant superoxide dismutase proteins in yeast. The main tools used in our laboratory are UV-visible spectroscopy and EPR spectroscopy, which is used to study free radicals.
Gunther, M.R., Peters, J.A., and Sivaneri, M.K. "Histidinyl radical formation in the self-peroxidation reaction of bovine copper-zinc superoxide dismutase". J. Biol. Chem. 277, 9160-9166, 2002.
Gunther, M.R., VanGilder, R., Fang, J., and Beattie, D.S. "Expression of a familial amyotrophic lateral sclerosis-associated mutant human superoxide dismutase in yeast leads to decreased mitochondrial electron transport". Arch. Biochem. Biophys. 431:207-214, 2004.
Gunther, M.R. and Donahue, J.A. "Bicarbonate and active site zinc modulate the self-peroxidation of bovine copper-zinc superoxide dismutase", Free Radic. Res. 41:1005-1016, 2007.