Vazhaikkurichi M. Rajendran
West Virginia University Health Science Center
United States of America
Works as Professor Biochemistry
Our laboratory is interested in investigating the electrolyte transport processes that regulate colonic fluid movement during physiological and pathophysiological (diarrhea and ulcerative colitis) conditions. We focus to identify the Ca2+-activated intermediate conductance (also known as KCNN4) K+ channel isoform that provides the driving force for Cl- secretion in several fluid secreting epithelial cells. To achieve this goal, we employ electrophysiology, biochemical, molecular and biophysical techniques.
O’Hara B, de la Rosa DA, Rajendran VM. "Multiple mineralocorticoid response elements localized in different introns regulate intermediate conductance k+ (kcnn4) channel expression in the rat distal colon". PLoS One. 2014 Jun 5; 9(6):e98695. doi: 10.1371/journal.pone.0098695. eCollection 2014. PMID: 24901797.PMC4047071
Coon S, Rajendran VM, Schwartz J, Singh SK. "Glucose-dependent insulinotropic polypeptide-mediated signaling pathways enhance apical PepT1 expression in intestinal epithelial cells". Am J Physiol Gastrointest Liver Physiol 308:G56-62, 2015. PMID:25377315. PMC4281688
Rajendran VM, Nanda Kumar NS, Tse CM, Binder HJ. "Na-H Exchanger Isoform-2 (NHE2) Mediates Butyrate-dependent Na+ Absorption in Dextran Sulfate Sodium (DSS)-induced Colitis." J Biol Chem. 2015 Oct 16;290(42):25487-96. doi: 10.1074/jbc.M115.654277. Epub 2015 Sep 8. PMID: 26350456