David P Siderovski

Biography

The long-standing research focus of the Siderovski has been in the field of regulators of heterotrimeric G protein signaling, having discovered the G-alpha GAP superfamily (‘RGS proteins’) in 1996 based on T-lymphocyte activation as well as yeast complementation studies. In 1999, Dr Siderovski also discovered the GoLoco motif protein family of G-alpha•GDP dissociation inhibitors based on bioinformatic analyses. These disclosures prompted Dr Siderovski being granted the renowned John J Abel Award from the American Society for Pharmacology and Experimental Therapeutics as the exceptional American pharmacologist under 40 of every 2004. Since these initial discoveries, his research into the function of novel regulators in G protein signal transduction has led to over 130 high-profile papers, reviews, and book chapters on the topic. As a complement to this basic science focus on G protein regulators, Dr Siderovski also has both industrial and academic experience in high-throughput screening and small molecule discovery programs, beginning with a multi-year stint in the 1990s at the AMGEN Institute (Toronto, Canada) responsible for leveraging basic research discoveries into new drug discovery projects at Amgen Inc. These early industrial efforts have resulted in three issued patents.

Research Interest

 G Proteins, Neurobiology and Brain Physiology, GPCR, Neuropharmacology, Signal Transduction, Animal Physiology, Signaling Pathways, Pharmacology, Cell Signaling, Radioligand Binding, Physiology, GPCR Signaling, Protein Kinases, Receptor, RAS, G-Protein-Coupled Receptors.