Michael Ruppert
Professor
Biochemistry
West Virginia University
United States of America
Biography
Course Co-Director (with J. Horabin, S. Lobo-Ruppert, and P. Detloff), Advanced Eucaryotic Molecular Genetics (BMG731); course offered alternate years, 8 one-hour lectures (1996-1998) Course Co-Director (with S. Lobo-Ruppert), Cell Cycle, upper level BMG course, biweekly journal club format supervised by Co-Directors (1997) Lecturer, Tumor Biology (PHY792, Sham Kakar, Dept. of Phys. & Biophys., Director), “Genetic changes during tumor progression”, two one-hour lectures (2000) Lecturer, Human Biochemistry and Genetics I (Medical Biochemistry, Kenneth Taylor, Dept. of Biochem. and Mol. Genet., Director) clinical correlation for “Mutations and Cancer”, one one-hour lecture yearly (2001-02) Lecturer, Cellular and Molecular Biology (CMB) IV (E. Sztul, Dept. of Cell Biology, Director), “Cell cycle”, two one-hour lectures to first year graduate students (1999-2002) Lecturer, Integrated Biomedical Sciences (Bob Diasio, Director), “Oncogenes”, two one-hour lectures yearly to first year graduate students Lecturer, Breast Cancer Causation (Coral Lamartiniere, Dept. of Pharmacology, Director), “Oncogenes and Tumor Suppressor Genes in Breast Cancer”, two one-hour lectures yearly Lecturer, Biology of Neoplasia (Dan Welch, Dept. of Pathology, Director), one two-hour lecture annually
Research Interest
identification and functional analysis of genes important in the early steps (initiation) of carcinoma genetic progression. We have focused upon two zinc finger transcription factors:
Publications
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Deng W, Vanderbilt DB, Lin CC, Martin KH, Brundage KM, Ruppert JM. "SOX9 inhibits beta-TrCP-mediated protein degradation to promote nuclear GLI1 expression and cancer stem cell properties." J.Cell Sci. 2015;128(6):1123-1138.
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Addison JB, Koontz C, Fugett JH, Creighton CJ, Chen D, Farrugia MK, Padon RR, Voronkova MA, McLaughlin SL, Livengood RH, Lin CC, Ruppert JM, Pugacheva EN, Ivanov AV. "KAP1 promotes proliferation and metastatic progression of breast cancer cells." Cancer Res. 2015;75(2):344-355.
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Farrugia MK, Vanderbilt DB, Salkeni MA, Ruppert JM. "Kruppel-like pluripotency factors as modulators of cancer cell therapeutic responses." Cancer Res. 2016;76(7):1677-1682.