Mohammed A Nayeem
Associate Professor
Pharmaceutical Sciences
West Virginia University
United States of America
Biography
Mohammed Nayeem, MSc, PhD., is an Assistant Professor in the Department of Pharmaceutical Sciences at West Virginia University, School of Pharmacy. Dr. Nayeem is serving as mentor and co-mentor to PhD. students, Postdoctoral Fellows, undergraduate students and lab technicians. Dr. Nayeem is the Principal Investigator (PI) in a currently funded NHLBI R01 grant (R01HL114559) entitled “Role of Cyp2j-epoxygenases, sEH and PPARs in adenosine-induced vascular response”.Dr. Nayeem’s laboratory investigates the mechanism of vascular regulation involves hypertension, salt-sensitive hypertension and coronary reactive hyperemia in adult and aging mice using regular diet /special diet (low salt & high salt) in A2A AR-null, sEH-null, Tie-2-cyp2j2 Tr, Tie-2-sEH Tr and their respective wild-type mice. Dr. Nayeem’s long-term goal is to identify and develop novel pharmacological agents to target in preventing the progression of prehypertension to hypertension in humans who have allelic variants (genetic polymorphism) that may act similarly to our transgenic (A2A AR-null, sEH-null, Tie-2-cyp2j2 Tr, Tie-2-sEH Tr) mice in the regulation of vascular tone and blood pressure.
Research Interest
cardiovascular Pharmacology
Publications
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Yadav VR, Hong KL, Zeldin DC, Nayeem MA. Vascular endothelial over-expression of soluble epoxide hydrolase (Tie2-sEH) enhances adenosine A1 receptor-dependent contraction in mouse mesenteric arteries: role of ATP-sensitive K+ channels. Molecular and cellular biochemistry. 2016 Nov 1;422(1-2):197-206.
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Rather SA, Nayeem MA, Agarwal S, Goyal N, Gupta S. Vascular complications in living donor liver transplantation at a highâ€volume center: Evolving protocols and trends observed over 10 years. Liver Transplantation. 2017 Apr 1;23(4):457-64.
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Hanif A, Edin ML, Zeldin DC, Morisseau C, Falck JR, Nayeem MA. Vascular Endothelial Over-Expression of Human Soluble Epoxide Hydrolase (Tie2-sEH Tr) Attenuates Coronary Reactive Hyperemia in Mice: Role of Oxylipins and ω-Hydroxylases. PloS one. 2017 Jan 5;12(1):e0169584.
