J. David Mcdonald
BIOLOGICAL SCIENCES
Wichita State University
United States of America
Biography
J. David have two separate research interests in the field of biology. First, I am interested in mammalian genetics and exploring how model systems like the laboratory mouse can be manipulated to yield useful models for human diseases. I have had success in that area by producing models for the human inborn error of metabolism phenylketonuria and also disorders of circadian behavior. Secondly, I have currently developed an interest in exploring antimicrobial strategies to augment the current set of tools, such as antibiotic therapy, that are losing their levels of effectiveness. I am starting to explore the infection phenomena of attachment and biofilm formation as potentially useful steps for inhibiting bacterial infection.
Research Interest
research interests in the field of biology, mammalian genetics, interested in exploring antimicrobial strategies to augment the current set of tools, such as antibiotic therapy
Publications
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McDonald, J.D. (2006). The Genetic Mouse Model for PKU. A chapter in PKU and BH4: Advances inPhenylketonuria and Tetrahydrobiopterin Research (Blau, N., editor). SPS Publishing (Heilbronn, Germany).
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Matalon, R., Michals-Matalon, K., Bhatia, G., Grechanina, E., Novikov, P., McDonald, J.D., Grady, J., Tyring, S.K., Guttler, F. (2006). Large neutral amino acids in the treatment of phenylketonuria (PKU). Journal of Inherited Metabolic Disease volume 29, issue 6, pages 732-738
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Steadman, S.A., McDonald, J.D., Andrews, J.S., Watson, N.D. (2008). Recovery and STR Amplification of DNA from RFLP Membranes. Journal of Forensic Sciences volume 53, issue 2, pages 349-358
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Sidell, N., Hao, L., Pasquali, M., McDonald, J.D. (2009). Carcinogenic effects in a phenylketonuria mouse model. PLoS Biology volume 4, issue 1, page 4292
