Dirk Albrecht
Assistant Professor
Biomedical Engineering
Worcester Polytechnic Institute
United States of America
Biography
Education: BS, Bioengineering University of California, San Diego 1997 BS, Biochemistry & Cell Biology University of California, San Diego 1997 PhD, Bioengineering University of California, San Diego 2005 Postdoc Neural Circuits and Behavior Rockefeller University, NYC 2007-2012. My research is in the area of microtechnology and neuroscience, with a focus on developing quantitative tools to study how neural signals govern behavior. My laboratory aims to investigate the molecular and genetic basis of neural circuit function and dynamics, to develop bioinformatic tools for analysis of high-content neural data, and to design rapid cellular and whole-organism screens for therapeutic drugs and genetic modulators affecting neural disease. Research in the lab develops an interdisciplinary set of skills in microfabrication, computation and modeling, lab automation/robotics, molecular biology, genetic engineering, optogenetics, microscopy, and quantitative systems biology. We work primarily with living model organisms, such as the nematode C. elegans, that are amenable to rapid genetic analysis and screening; we aim to then translate our findings toward clinical applications in the treatment of neural disorders. I look forward to teaching students about topics related to quantitative biology, including the source, measurement, perturbation, and analysis of biological signals. I enjoy working together with students of different backgrounds-- engineering, biology, chemistry, physics and mathematics-- as student projects and our lab research benefit greatly from the complementary approaches of these fields. As a group, we aim to accelerate biomedical discovery by applying engineering principles to increase efficiency and decrease costs. It is a great reward to mentor students to help them become independent scientists with the strong interdisciplinary skills they will need to advance the future of healthcare.
Research Interest
Biological microtechnology and bioMEMS; Neural dynamics and behavior, neuropeptide signaling; Quantitative systems analysis and modeling; High-throughput genetic/chemical screening
Publications
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Oxtocin/vasopressin-related peptides have an ancient role in reproductive behavior - 2012
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Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans - 2013
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High-throughput imaging of neuronal activity in Caenorhabditis elegans - 2013
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Microfluid Devices Behavioral Analysis, Microscopy, and Neuronal Imaging in Caenorhabditis elegans - 2015
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A Circuit for Gradient Climbing in C. elegans Chemotaxis - 2015