James B. Lucot

Biography

Education History: Biology/Psychology, B.S. (1973), University of Pittsburgh, Pittsburgh, PA Neurobiology, Ph.D. (1977), University of North Carolina, Chapel Hill, NC Pharmacology and Toxicology, Postdoctoral (1977-1980), University of Chicago, Chicago, IL

Research Interest

Research background Intersection of toxicology and neuroscience at the level of behavior and neurochemistry Applying neurobehavioral assessment, neurochemical analysis and measurement of catecholamines in urine to characterize animal models of a wide range of disorders . His research approach was to evaluate the interactions between behavior, drugs, and brain chemistry. This approach provided the flexibility to undertake a wide range of projects, to pursue interesting findings, and join in collaborative research. The laboratory worked with multiple researchers to characterize knockout models using the research techniques available in his laboratory. These studies expanded the knowledge to be gained from such models without requiring additional subjects because they can be conducted in the same animals being used for the primary purpose of the experiment. The results extended the knowledge base, raised new hypothesis and generated additional components to grant proposals based on the results. The approach was also used to provide standardized proof of efficacy for tests of novel therapies. Earlier work involved Gulf War Illness, development of a novel neuroprotectant against nerve agent status epilepticus-induced neurodegeneration and resolved and refined a new approach to treatment of nausea and vomiting.